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Larkana is a city in the north-west of the Sindh province of Pakistan, where the historic Indus River flows in south of the city. It is home to the Indus Valley Civilization site Mohenjo-Daro, which is larger in size than Babylonia and Assyria.

Larkana is a monsoon climatic region. Summer is extremely hot as temperature reaches at 53 °C and winter is a little cool as temperature drops to -2 °C.